(R)-3-MORPHOLINECARBOXYLIC ACID HCL
(R)-morpholine-3-carboxylic acid
CAS: 106825-81-4
Molecular Formula: C5H9NO3
(R)-3-MORPHOLINECARBOXYLIC ACID HCL - Names and Identifiers
(R)-3-MORPHOLINECARBOXYLIC ACID HCL - Physico-chemical Properties
| Molecular Formula | C5H9NO3 |
| Molar Mass | 131.13 |
| Density | 1.239 |
| Boling Point | 298 ºC |
| Flash Point | 134 ºC |
| Vapor Presure | 5.69E-05mmHg at 25°C |
| pKa | 2.11±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| MDL | MFCD03426306 |
(R)-3-MORPHOLINECARBOXYLIC ACID HCL - Introduction
(R)-3-Carboxymorpholine is an organic compound with the molecular formula C5H9NO2 and the structural formula CH3CH(OH)CH(COOH)NH2.
Nature:
(R)-3-carboxymorpholine is a colorless crystal or a white powder with low solubility. It is a chiral compound with optical rotation and can rotate the direction of plane polarized light. Its melting point is 185-190°C.
Use:
(R)-3-carboxymorpholine is an important synthetic intermediate, which has a wide range of applications in the pharmaceutical, pesticide, dye and fragrance industries. It can be used to synthesize antibiotics, anticancer drugs, β-lactam antibiotics and other drugs. In addition, it can also play an important role as a ligand in metal-catalyzed reactions.
Preparation Method:
(R)-3-carboxymorpholine can be obtained by reduction, hydroxymethylation and carboxylation of acetylacetone. Specific steps are as follows:
1. Acetylacetone and excess hydrogen are subjected to a reduction reaction in the presence of a catalyst to obtain (R)-2-hydroxypentanone.
2. Reaction of (R)-2-hydroxypentanone with formaldehyde to perform hydroxymethylation to obtain (R)-2-hydroxy-2-methoxypentanone.
3. Finally, (R)-2-hydroxy-2-methoxypentanone is reacted with dilute acid for carboxylation to obtain (R)-3-carboxymorpholine.
Safety Information:
(R)-3-carboxymorpholine has low toxicity, but it is still necessary to pay attention to safe operation. During use, direct contact with skin and eyes should be avoided. At the same time, maintain good ventilation and take appropriate protective measures, such as wearing protective gloves and goggles. If inhaled or ingested, get medical help immediately.
Nature:
(R)-3-carboxymorpholine is a colorless crystal or a white powder with low solubility. It is a chiral compound with optical rotation and can rotate the direction of plane polarized light. Its melting point is 185-190°C.
Use:
(R)-3-carboxymorpholine is an important synthetic intermediate, which has a wide range of applications in the pharmaceutical, pesticide, dye and fragrance industries. It can be used to synthesize antibiotics, anticancer drugs, β-lactam antibiotics and other drugs. In addition, it can also play an important role as a ligand in metal-catalyzed reactions.
Preparation Method:
(R)-3-carboxymorpholine can be obtained by reduction, hydroxymethylation and carboxylation of acetylacetone. Specific steps are as follows:
1. Acetylacetone and excess hydrogen are subjected to a reduction reaction in the presence of a catalyst to obtain (R)-2-hydroxypentanone.
2. Reaction of (R)-2-hydroxypentanone with formaldehyde to perform hydroxymethylation to obtain (R)-2-hydroxy-2-methoxypentanone.
3. Finally, (R)-2-hydroxy-2-methoxypentanone is reacted with dilute acid for carboxylation to obtain (R)-3-carboxymorpholine.
Safety Information:
(R)-3-carboxymorpholine has low toxicity, but it is still necessary to pay attention to safe operation. During use, direct contact with skin and eyes should be avoided. At the same time, maintain good ventilation and take appropriate protective measures, such as wearing protective gloves and goggles. If inhaled or ingested, get medical help immediately.
Last Update：2024-04-09 21:11:58
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